One drunken night, two friends admit that they wish they had the other's life. Mitch Reynolds (Ryan Reynolds) thinks Dave (Jason Bateman) has it all: A beautiful, loving family and a high-paying job at a prestigious law firm. But Dave thinks Mitch's stress-free life without obligation or consequence is the real dream come true. The next morning they wake up, hung over, in each other's bodies and proceed to freak out! With time not on their side, Mitch and Dave comically struggle to avoid completely destroying each other's lives before they can find a way to get their old ones back.