Desperate to get her son into a better school, single mom Rose (Amy Adams) persuades her slacker sister Norah (Emily Blunt) to join her in the crime scene cleanup business to make some quick cash. With the help of their ill-fated salesman father (Alan Arkin), they climb the ranks in a very dirty job, finding themselves up to their elbows in murders, suicides, and... specialized situations. But underneath the dust and grime they also come to discover a true respect for one another, and create a brighter future for the entire Lorkowski family.