Becker centers on the life of Dr. John Becker, a cantankerous, yet dedicated and talented physician, who, in spite of his constant rants, has a decent heart underneath the sarcasm. Becker will continue to unleash his views at the local diner, even in Reggie's continuing absense. Jake (Alex Desert), the blind proprietor of the local newsstand continues to turn a deaf ear to John. Bob, Becker's brash, obnoxious apartment super (Saverio Guerra), persists in annoying virtually everyone. At the office, Becker's head nurse Margaret (Hattie Winston) continues to make order out of chaos, keeping John and his space-cadet nurses-aid Linda (Shawnee Smith) in line. New to the neighborhood is Chris Konnors (Nancy Travis), Becker's new neighbor, with whom he must contend on a daily basis. Although her positive attitude is a major annoyance to Becker, he slowly begins to have feelings for her.